Tizanidine

In stock

2mg

from 40,92 £

In brief

In our pharmacy, you can buy tizanidine without a prescription, with delivery in 9–21 days throughout the United Kingdom. Discreet and anonymous packaging.
Tizanidine is used to treat muscle spasticity associated with conditions such as multiple sclerosis or spinal cord injury; it is a central alpha-2 adrenergic agonist that reduces spasticity by inhibiting presynaptic motor neurone activity and decreasing excitatory neurotransmitter release.
The usual dose of tizanidine starts at 2 mg (typically at bedtime or during the day) with gradual titration; maintenance dosing is commonly 6–36 mg per day in divided doses, and the maximum recommended dose is generally 36 mg per day.
The form of administration is oral tablets (commonly 2 mg and 4 mg strengths) taken by mouth.
The effect of the medication begins within about 30–60 minutes after oral administration.
The duration of action is relatively short, usually around 3–6 hours per dose.
Avoid alcohol while taking tizanidine, as alcohol increases sedation, dizziness and the risk of low blood pressure and impaired coordination; alcohol may also worsen liver effects.
The most common side effect is drowsiness (sedation), with other frequent effects including dizziness, dry mouth and weakness.
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Basic tizanidine information

INN (international nonproprietary name): Tizanidine (as tizanidine hydrochloride)
Brand names available in the United Kingdom: Zanaflex; generic tizanidine
ATC code: M03BX02
Forms and dosages: Tablets 2 mg, 4 mg
Registration status in the United Kingdom: MHRA-licensed
OTC / Rx classification: Prescription-only medicine (POM)

Legal status and availability in the UK

Tizanidine is a prescription-only medicine (POM) in the UK.

For private purchase, our pharmacy offers discreet delivery to the United Kingdom in 5‑14 days, though prescription verification is usually required for safety.

Indications and typical patients

Licensed uses and common off‑label scenarios

Clinicians usually prescribe tizanidine for intermittent spasticity where lowering muscle tone will help mobility or reduce pain.

Typical UK referrals come from neurology, rehabilitation medicine or pain clinics with functional goals such as improved transfers, fewer cramps or better sleep.

Off‑label use can include acute muscle spasm after soft‑tissue injury, but evidence for this is limited and prescribers consider alternatives where possible.

Choice between tizanidine and other agents such as baclofen or diazepam depends on the individual patient’s tolerance, comorbidity and goals.

In elderly and polypharmacy patients start low and monitor for hypotension, sedation and increased fall risk.

Typical indications versus expected benefit

Indication	Expected benefit
Spasticity from multiple sclerosis	Reduced tone, fewer nocturnal spasms, improved sleep
Spinal cord injury‑related spasm	Short‑term relief of painful spasms and facilitation of physiotherapy
Post‑stroke spasticity (intermittent)	Improved comfort and easier passive range of motion
Acute soft‑tissue muscle spasm (off‑label)	Possible short‑term reduction in cramp severity where other agents unsuitable

How tizanidine works — practical mechanism

Pharmacodynamics and what patients notice

Tizanidine acts as an alpha‑2 adrenergic agonist that reduces excitatory signalling from spinal interneurons, which in turn lowers muscle tone.

Patients commonly notice decreased stiffness and fewer spasms within a few hours after a dose.

Metabolism occurs predominantly via the liver enzyme CYP1A2, so drugs that inhibit CYP1A2 raise tizanidine exposure and adverse effects.

Explaining the mechanism in plain language helps adherence: it “quiets overactive nerves that tighten muscles”.

Mechanism: Alpha‑2 agonist reducing spinal excitatory input.
Onset: Often within a few hours for symptomatic relief.
Duration: Short‑acting; doses commonly repeated every 6–8 hours.
Metabolism: Hepatic via CYP1A2 — interactions are clinically important.

Formulations, strengths and packaging

Typical tablet strengths

Tizanidine is usually supplied as immediate‑release tablets in common strengths such as 2 mg and 4 mg.

In the UK generic supply tends to dominate.

Dosing, titration and administration

Practical starter regimens and titration rules

Start low and go slow to balance benefit against sedation and hypotension.

Typical initiation is 2 mg at bedtime, increasing by 2–4 mg every three days according to effect and tolerability.

Many adults take divided doses every 6–8 hours with most patients remaining on much lower doses than the licence maximum.

The maximum daily dose is 36 mg, but many patients achieve symptom control at substantially lower total doses.

Take with or without food and avoid late‑day doses if daytime drowsiness is a problem.

Use caution in renal impairment and adjust or increase monitoring in hepatic impairment because exposure rises markedly.

Titration checklist

Initiate 2 mg at bedtime to assess sedation.
Increase by 2–4 mg every 3 days if needed and tolerated.
Divide doses every 6–8 hours rather than single large doses.
Avoid concurrent potent CYP1A2 inhibitors during titration.
Document dose changes and reassess fall risk, especially in older adults.

Contraindications and cautions

Absolute and relative contraindications

Known hypersensitivity to tizanidine is an absolute contraindication.

Concurrent use with potent CYP1A2 inhibitors such as ciprofloxacin or fluvoxamine is a contraindication because of the risk of severe hypotension and sedation.

Severe hepatic impairment is a contraindication or reason to avoid tizanidine due to increased exposure.

Relative cautions include elderly frail patients, marked baseline hypotension or bradycardia, and concurrent multi‑drug CNS depressant use.

Use in pregnancy and breastfeeding should only occur if benefits clearly outweigh risks, because data are limited.

Contraindication: Potent CYP1A2 inhibitors — risk of dangerous hypotension and sedation.
Contraindication: Severe hepatic impairment — markedly increased exposure.
Caution: Elderly, frail, or those with high fall risk.
Caution: Pregnancy and breastfeeding only if necessary.

Interactions — drugs and alcohol

High‑risk interactions and management

Potent CYP1A2 inhibitors such as ciprofloxacin and fluvoxamine markedly increase tizanidine plasma concentrations and are usually contraindicated together.

CNS depressants — including opioids, benzodiazepines, gabapentinoids and alcohol — amplify sedation and may increase the risk of respiratory depression.

Antihypertensive medicines can add to tizanidine‑related hypotension; monitor blood pressure closely when starting or changing doses.

Ciprofloxacin — contraindicated in combination.
Fluvoxamine — contraindicated in combination.
Opioids and benzodiazepines — increased sedation risk.
Alcohol — avoid while taking tizanidine.

Side effects, monitoring and red flags

Common, serious and when to seek help

Common side effects include drowsiness, dry mouth, dizziness, muscle weakness and hypotension; these often prompt dose reduction or night dosing.

Serious issues to watch for are syncope, severe hypotension, marked hepatic enzyme elevations and withdrawal symptoms if treatment is stopped abruptly.

Baseline and periodic monitoring should include blood pressure and heart rate, with liver function tests if symptoms suggest hepatic injury or during prolonged therapy.

In older adults reassess fall risk after each dose change.

Side effect	Monitoring / action
Drowsiness	Advise bedtime dosing; avoid driving until effect known
Hypotension / dizziness	Check BP; consider dose reduction or discontinuation
Elevated liver enzymes	Perform LFTs if symptomatic; stop if severe
Withdrawal on abrupt stop	Taper dose when stopping to avoid rebound symptoms

Seek immediate medical help for severe dizziness, fainting, breathing difficulty or signs of severe liver injury such as jaundice.

Practical counselling points for patients

Dosing timing, driving and daily life tips

Advise patients to try the first doses at home at bedtime until they know how tizanidine affects them.

Warn against driving or operating machinery until they are certain of their alertness.

Recommend avoiding alcohol and to contact the pharmacy or prescriber before starting antibiotics, especially ciprofloxacin, or new antidepressants.

Offer simple sleep hygiene tips and suggest shifting doses to night if daytime somnolence is a problem.

Agree a follow‑up plan with the prescriber to review effectiveness and side effects.

Storage, handling and disposal

Practical storage and patient instructions

Store tizanidine at room temperature, away from moisture and out of reach of children.

Keep tablets in their original packaging so batch and expiry details are retained.

Advise safe disposal via the pharmacy medicine take‑back scheme rather than household waste.

Alternatives and therapy positioning

Baclofen, diazepam, botulinum toxin and others

Tizanidine is one therapeutic option among muscle relaxants and is best positioned where short‑acting reduction of tone is needed and CYP interactions are manageable.

Baclofen is often used first‑line for generalised spasticity and has different adverse‑effect and withdrawal profiles.

Diazepam can be useful for acute severe spasm or when anxiety is comorbid, but carries sedation and dependency risks.

Botulinum toxin is a focal therapy suited to localised spasticity when injections are technically feasible and appropriate.

Agent	Onset	Common adverse effects	Typical use
Tizanidine	Hours	Sedation, hypotension, CYP1A2 interactions	Intermittent spasticity, short‑term use
Baclofen	Days	Weakness, sedation, withdrawal risk	Generalised spasticity, intrathecal option for severe cases
Diazepam	Minutes–Hours	Drowsiness, dependence	Acute severe spasm or anxiety comorbidity
Botulinum toxin	Days–Weeks	Local weakness, injection site pain	Focal spasticity

FAQs and follow‑up care

Common patient questions and escalation steps

A follow‑up review around one to two weeks after starting treatment is recommended, or sooner if worrying side effects occur.

Encourage patients to report adverse reactions through the Yellow Card Scheme and to keep a simple symptom diary to guide dose adjustments with their clinician.

Common questions include:

Will it make me sleepy? Drowsiness is common; taking the dose at night can help.
Can I drink alcohol? No, avoid alcohol while taking tizanidine.
What if I am prescribed ciprofloxacin? Tell the prescriber or pharmacist, because ciprofloxacin must not be taken together with tizanidine.
When will I feel benefit? Often within a few hours of a dose.

Delivery across the United Kingdom

City	Region	Delivery Time
London	England	9–21 days
Birmingham	England	9–21 days
Manchester	England	9–21 days
Glasgow	Scotland	9–21 days
Leeds	England	9–21 days
Liverpool	England	9–21 days
Edinburgh	Scotland	9–21 days
Bristol	England	9–21 days
Newcastle Upon Tyne	England	9–21 days
Sheffield	England	9–21 days
Cardiff	Wales	9–21 days
Belfast	Northern Ireland	9–21 days
Nottingham	England	9–21 days
Leicester	England	9–21 days
Coventry	England	9–21 days