Viagra With Dapoxetine

Basic Viagra with dapoxetine information

• INN (international nonproprietary name): Sildenafil (a phosphodiesterase type 5 inhibitor) and Dapoxetine (a selective serotonin reuptake inhibitor).
• Brand names available in the United Kingdom: no licensed combination brand; Priligy is the licensed brand of dapoxetine alone
• ATC code: The fixed combination has no unique WHO ATC code; sildenafil is G04BE03 and dapoxetine is G04BX14
• Forms and dosages: Oral film-coated tablets commonly sold as 100 mg sildenafil + 60 mg dapoxetine, 50 mg + 30 mg, and 100 mg + 30 mg in blister strips of 4 or 10 tablets
• Registration status in the United Kingdom: Not licensed in the UK as a fixed-dose combination
• OTC / Rx classification: Sildenafil and dapoxetine are each prescription-only medicines (POM) in the UK

Legal status and availability in the UK

Viagra with dapoxetine is not licensed in the UK as a combination; sildenafil and dapoxetine are prescription-only medicines (POM) in the UK.

In our online pharmacy, Viagra with dapoxetine is available without a prescription, with discreet delivery to the United Kingdom in 9–21 days.

Product overview — what the tablet contains

Active ingredients (INN) and mechanism

Sildenafil is the International Nonproprietary Name for the PDE5 inhibitor that improves penile blood flow and supports erection when sexual stimulation is present.

Dapoxetine is the INN for a short-acting selective serotonin reuptake inhibitor that delays ejaculation by altering serotonin signalling.

The fixed tablet combines a PDE5 inhibitor and an SSRI to address both erectile dysfunction and premature ejaculation on demand.

Common strengths and formulations

Typical marketed strengths include 100 mg sildenafil + 60 mg dapoxetine, 50 mg + 30 mg and 100 mg + 30 mg.

Film-coated oral tablets in blister packs of 4 or 10 are commonly supplied.

Sildenafil

Phosphodiesterase type 5 inhibitor; increases penile blood flow during sexual stimulation.

Dapoxetine

Short-acting SSRI; delays ejaculation by enhancing serotonergic neurotransmission.

Who should consider this product

Ideal patient profile

Adult men with confirmed erectile dysfunction and bothersome premature ejaculation who have not achieved satisfactory results with monotherapy or who prefer a single on‑demand tablet are suitable candidates.

Appropriate selection follows a clinical assessment that rules out reversible causes and evaluates cardiovascular and mental‑health status.

When to avoid combination use

The combination should not be used by men taking nitrates, those with unstable cardiovascular disease, or those with moderate to severe liver or kidney impairment.

Patients with major depression or a history of suicidal ideation require specialist review before dapoxetine use.

• Inclusion criteria: adult men with coexisting ED and PE, previous inadequate response to single agents, and no contraindicating comorbidity.
• Exclusion criteria: concurrent nitrate therapy, unstable cardiac disease, moderate–severe hepatic/renal impairment, severe psychiatric instability.

Licensing, regulation and UK position

MHRA context

The fixed‑dose sildenafil + dapoxetine combination does not have a unique WHO ATC code and is not licensed as a fixed combination in the UK.

Legal status in the UK

In the UK both sildenafil and dapoxetine are prescription‑only medicines and the fixed combination is generally not UK‑authorised as a licensed product.

Dosage, timing and administration

Standard regimens and timing

Take the tablet 1–3 hours before sexual activity for on‑demand dosing.

Usual starting dose commonly cited is Sildenafil 100 mg + Dapoxetine 60 mg, with lower strength options available.

Do not take more than one dose in a 24‑hour period.

Dose adjustments and special populations

Elderly men may be more sensitive and should be considered for lower initial doses or closer monitoring.

The combination is contraindicated in moderate–severe hepatic or renal impairment and is not indicated in children or adolescents.

Absolute and relative contraindications

Absolute contraindications

Hypersensitivity to sildenafil, dapoxetine or any excipients is an absolute contraindication.

Concurrent nitrate therapy is an absolute contraindication because of the risk of severe hypotension.

• Unstable cardiovascular disease (recent myocardial infarction, stroke, unstable angina) — do not use.
• Moderate to severe hepatic or renal impairment — do not use.
• Bipolar disorder or major depression with suicidal ideation — do not use.

Relative contraindications (proceed with caution)

Stable cardiovascular disease may be treated with combination therapy after clinician review and risk assessment.

Concurrent alpha‑blockers or antihypertensives increase orthostatic hypotension risk and require monitoring and dosage review.

• Mild hepatic or renal impairment — assess and monitor plasma effect; consider lower starting dose.
• Co‑prescription with MAO inhibitors — ensure a 14‑day washout before starting dapoxetine.

Drug interactions and management

High-risk interactions

Concurrent nitrates cause potentially life‑threatening hypotension and are an absolute contraindication.

Potent CYP3A4 inhibitors (for example some azole antifungals, certain macrolides and some HIV protease inhibitors) may raise sildenafil plasma levels and increase adverse effects.

Combining dapoxetine with other serotonergic drugs (other SSRIs, SNRIs, MAOIs, triptans, linezolid) increases the risk of serotonin syndrome.

Managing interactions

Tell your prescriber or pharmacist about all current medicines, especially nitrates and potent CYP3A4 inhibitors.

A 14‑day MAOI washout is advised; where interactions are unavoidable, alternative agents or prescriber review are needed.

Side effects, adverse events and reporting

Common, expected effects

Sildenafil‑related adverse effects commonly include headache, flushing, nasal congestion, dyspepsia and transient visual changes.

Dapoxetine‑related adverse effects commonly include nausea, diarrhoea, insomnia, anxiety and dry mouth.

Combination use commonly increases dizziness and the risk of orthostatic hypotension.

Serious adverse signs and reporting

Priapism, an erection lasting longer than four hours, is a medical emergency requiring immediate attendance at A&E.

Signs of serotonin syndrome — agitation, hyperthermia, confusion, rapid heartbeat — require urgent medical assessment.

Any suspected adverse reaction should be reported via the UK Yellow Card Scheme to the MHRA.

Monitoring, follow-up and safety checks

Baseline assessments

A cardiovascular history and current medication list, including any nitrates or serotonergic drugs, should be reviewed before use.

Measure blood pressure when clinically appropriate and confirm recent liver and renal function results from the prescriber for at‑risk patients.

Ongoing monitoring and when to refer

Report persistent adverse effects, fainting, new mood changes or suicidal thoughts, and erections lasting more than four hours.

If side effects persist beyond a few doses or interactions emerge, speak to the prescriber about dose adjustment or discontinuation.

Comparisons with alternative therapies

Tadalafil or vardenafil combinations

Tadalafil combined with dapoxetine offers a longer duration of erectile support — up to 36 hours for tadalafil — versus the shorter, on‑demand action of sildenafil.

Vardenafil combinations are available less commonly and may share similar interaction and contraindication profiles to sildenafil combinations.

Monotherapy vs combination advantages

Monotherapy options include dapoxetine alone (Priligy) for PE or sildenafil alone for ED and may be preferable when one condition predominates or when combination contraindications exist.

Combination therapy advantages are convenience, co‑ordinated dosing and addressing both ED and PE together, while disadvantages include a larger adverse‑effect burden and licensing considerations.

Storage

Store at 15–30°C, keep in the original blister until use and protect from moisture and direct sunlight.

Counselling points

Key counselling points

Tell your prescriber or pharmacist about nitrates, cardiovascular history, psychiatric history and current medicines, especially serotonergic drugs and CYP3A4 inhibitors.

Timing: take 1–3 hours before sexual activity and do not take more than one dose in 24 hours.

Dizziness may occur; avoid excessive alcohol and take care when driving if affected.

Common patient questions

• Q: “What should I do if I feel low or have suicidal thoughts?” A: “Stop the medication and seek urgent review with your prescriber or emergency mental health services.”
• Q: “What if erection lasts more than four hours?” A: “Attend A&E immediately for priapism treatment.”
• Q: “Can I drink alcohol?” A: “Limit alcohol — excess can increase dizziness and reduce effectiveness.”

FAQs and overdose guidance

Concise patient‑facing FAQs

• Can I drive after taking this tablet? Avoid driving if you feel dizzy or somnolent after dosing.
• What happens if I miss my intended sexual activity? Do not re‑dose within 24 hours; use the next planned occasion instead.
• Can I drink alcohol? Limit alcohol; it increases the risk of dizziness and may worsen side effects.

Overdose and emergency instructions

In case of suspected overdose seek urgent medical attention and inform emergency staff about the medicines taken.

For priapism (erection >4 hours), severe hypotension, agitation or signs of serotonin syndrome seek immediate emergency care.

Sildenafil and dapoxetine are prescription‑only medicines in the UK; follow prescriber instructions and report adverse reactions via the MHRA Yellow Card scheme.

Delivery across the United Kingdom