Zenegra

In stock

50mg · 100mg

from 35,97 £

In brief

In our pharmacy, you can buy Zenegra without a prescription, with delivery in 9–21 days throughout the United Kingdom. Discreet and anonymous packaging.
Zenegra is used to treat erectile dysfunction; it is a phosphodiesterase type 5 (PDE5) inhibitor that increases cGMP levels, causing smooth muscle relaxation and increased blood flow to the penis (sexual stimulation is required).
The usual dose for erectile dysfunction is 50 mg taken about 1 hour before sexual activity; doses can be reduced to 25 mg or increased to 100 mg depending on efficacy and tolerability, with a maximum of 100 mg in 24 hours.
The form of administration is an oral tablet (blue film-coated tablets in 25 mg, 50 mg and 100 mg), usually supplied in blister packs.
The effect typically begins within 30–60 minutes (may be faster or slower depending on food intake; high‑fat meals can delay onset).
The duration of action is generally around 4–5 hours.
Avoid excessive alcohol when taking Zenegra — alcohol can increase the risk of dizziness and reduce the drug’s effectiveness; do not use with nitrates or recreational “poppers”.
The most common side effect is headache.
Would you like to try Zenegra without a prescription?

Basic Zenegra information

INN (international nonproprietary name): Sildenafil (also referred to as sildenafil citrate in product labelling).
Brand names available in the United Kingdom: Zenegra (unlicensed sildenafil product); licensed sildenafil is supplied as generic sildenafil.
ATC code: G04BE03 (G04: urologicals; BE: drugs used in erectile dysfunction; 03: sildenafil).
Forms and dosages: Tablet strengths 25 mg, 50 mg, 100 mg.
Manufacturers in the United Kingdom: Alkem Laboratories Ltd.
Registration status in the United Kingdom: Not licensed in the UK.
OTC / Rx classification: Sildenafil is a prescription-only medicine (POM) in the UK; one specific pharmacy-only sildenafil 50 mg product is available without prescription.

Legal status and availability in the UK

In our online pharmacy, Zenegra is available without a prescription, with discreet delivery to the United Kingdom in 5‑14 days.

Sildenafil is a prescription-only medicine (POM) in the UK, with a limited non-prescription option for one specific pharmacy-only sildenafil 50 mg product. Zenegra is not licensed in the UK.

Product snapshot — composition, brands and packaging

Active ingredient and ATC classification

What is the active medicine inside Zenegra and how is it classified?

INN: Sildenafil (often labelled as sildenafil citrate in product information).
Brand name: Zenegra is the trade name used by Alkem Laboratories Ltd.
ATC: G04BE03 — urologicals for erectile dysfunction specific to sildenafil.

Packaging, strengths and forms

How does Zenegra usually look and in what strengths does it come?

Zenegra typically appears as blue film‑coated tablets marked for dose strength and commonly supplied by Alkem in 50 mg and 100 mg strengths.

Tablets are available in 25 mg, 50 mg and 100 mg strengths.

Strength	Typical pack sizes
25 mg	Blisters of 1, 2, 4, or 10 tablets
50 mg	Blisters of 1, 2, 4, or 10 tablets
100 mg	Blisters of 1, 2, 4, or 10 tablets

Who Zenegra is for: indications and limitations

Indications and expected effects

Who should consider Zenegra and what should they expect?

Zenegra is indicated for erectile dysfunction in adult men and facilitates erection only in the presence of sexual stimulation.

It is not an aphrodisiac and will not produce an erection without arousal.

Zenegra is not indicated for women or children and is used as an on‑demand treatment taken before sexual activity unless a clinician advises otherwise.

When not to use — quick contraindications

Which situations make sildenafil unsafe?

Absolute contraindications: concurrent nitrate therapy of any form and known hypersensitivity to sildenafil or any excipient.
Other absolute concerns: recent stroke or myocardial infarction, unstable angina, severe hepatic or renal impairment without supervision, retinitis pigmentosa (inherited retinal disease).

Warning: Never take sildenafil with nitrate medicines due to the risk of severe, life‑threatening hypotension.

Dosage guide and practical administration

Typical dosing for ED and adjustments

How much should most men start with and when are adjustments needed?

Dose	Recommendation
25 mg	Start dose for elderly or patients with significant hepatic/renal impairment or where interaction risk exists.
50 mg	Standard starting dose for most adult men; take about 30–60 minutes before sexual activity.
100 mg	Maximum single dose; may be used when 50 mg is insufficient and tolerated well. Do not exceed 100 mg in 24 hours.

Elderly patients or those with liver or kidney impairment should start at a lower dose such as 25 mg and titrate cautiously under supervision.

Timing, missed dose and overdose

What practical rules should patients follow about timing and safety?

Onset is typically 30–60 minutes, and absorption may be delayed if taken with a high‑fat meal.

Missed‑dose rules are not relevant for single‑use on‑demand dosing.

In case of overdose, urgent medical attention is required; watch for severe hypotension, prolonged erection (priapism) and vision changes.

Call emergency services or attend A&E for severe hypotension or prolonged erection lasting more than four hours.
Bring the medication packaging and any other medicines being taken to help clinicians assess interactions.
If mild symptoms occur after overdose, present to urgent care for observation and monitoring.

Pharmacology in plain terms

How sildenafil works

What does sildenafil do in the body?

Sildenafil inhibits phosphodiesterase type 5 (PDE5) in penile smooth muscle which enhances nitric oxide–mediated vasodilatation and increases blood flow into the corpus cavernosum during sexual stimulation.

It does not cause spontaneous erections without sexual arousal.

Onset, duration and metabolism

What are the typical pharmacokinetic landmarks?

Onset: Approximately 30–60 minutes under usual conditions.
Duration: Effect commonly lasts 4–6 hours though individual response varies.
Metabolism: Predominantly metabolised by CYP3A4; interactions with CYP3A4 inhibitors can raise sildenafil levels.
Half‑life / Peak: Peak plasma levels occur within an hour in many patients and the elimination half‑life supports the typical 4–6 hour window of effect.

Contraindications, precautions and monitoring

Absolute and relative contraindications

Which conditions absolutely prevent sildenafil use and which require caution?

Absolute contraindications	Relative contraindications / precautions
Concurrent nitrate therapy; known hypersensitivity to sildenafil; recent MI or stroke; unstable angina; severe hepatic or renal impairment without supervision; retinitis pigmentosa.	Uncontrolled hypertension; predisposition to priapism; significant cardiovascular disease; concomitant potent CYP3A4 inhibitors; co‑administration with alpha‑blockers needs caution.

Monitoring and when to consult

Who needs extra checks before or during treatment?

Patients on antihypertensives or alpha‑blockers should have blood pressure reviewed before starting sildenafil to reduce the risk of orthostatic hypotension.

Elderly patients and those with cardiac disease should begin at lower doses and be reviewed by their prescriber if concerns arise.

Any new visual or auditory symptoms, or a painful or prolonged erection, require immediate medical attention.

Side effects — common, less common and red flags

Expected side effects and frequency

What side effects should patients expect and how common are they?

Common mild to moderate adverse effects include headache, flushing, nasal congestion, dyspepsia, dizziness, muscle pain and transient visual disturbances such as a blue‑tinted vision.

Most side effects are self‑limited and resolve without treatment; simple measures such as rest and over-the-counter analgesia for headache may help.

Serious reactions and what to do

Which events are rare but require urgent action?

Priapism (erection lasting more than four hours) — urgent urological assessment is required to avoid permanent injury.
Sudden hearing loss or sudden visual loss — stop the medicine and seek emergency care.
Severe hypotension, especially when combined with nitrates — call emergency services immediately.

Drug interactions and management

High‑risk interactions

Which drugs must never be combined with sildenafil?

Drug/class	Risk	What to do
Nitrates (e.g. nitroglycerin)	Life‑threatening hypotension	Contraindicated — do not take sildenafil; seek immediate medical review if nitrates are required.
Potent CYP3A4 inhibitors (e.g. ritonavir, some azole antifungals, clarithromycin)	Increased sildenafil plasma levels and side effects	Consider dose reduction and clinical review; avoid 100 mg when strong inhibitors are present.
Alpha‑blockers and antihypertensives	Orthostatic hypotension	Blood pressure should be checked and dosing staggered where appropriate; rise slowly from sitting or lying positions.

Lifestyle interactions

What lifestyle advice goes alongside the dosing information?

Alcohol can exacerbate dizziness and the risk of hypotension and should be used in moderation when taking sildenafil.

Grapefruit juice may increase sildenafil levels via CYP3A4 inhibition and should be avoided around dosing where possible.

Zenegra compared with other erectile dysfunction medicines

Comparative overview

How does Zenegra compare to other ED medicines on clinic and in practice?

Zenegra contains the same active ingredient as the licensed sildenafil originator product and licensed sildenafil generics.

Tadalafil offers a longer duration of action and vardenafil (Levitra) has a different onset and tolerability profile.

Key differences for most patients are onset speed, duration of effect and interaction profile.

Practical switching and choice factors

Which factors guide the choice between sildenafil and alternatives?

Frequency of sexual activity — on-demand sildenafil suits occasional use while tadalafil may suit frequent sexual activity due to longer duration.
Onset needs — some patients prefer agents with rapid onset depending on planning and spontaneity.
Comorbidities and drug interactions — select an agent with the lowest interaction risk for that individual.

Packaging and storage

How Zenegra looks and how to store it

Authentic Zenegra is typically a blue film‑coated tablet marked with the strength and supplied in blister packs that include manufacturer details such as Alkem Laboratories.

Store tablets below 25°C, protect from light and moisture, and keep in the original packaging until use.

Check for manufacturer name and batch number on the blister.
Ensure expiry date is present and legible.

Practical counselling points

Points to discuss with a pharmacist or prescriber

What should be confirmed before using sildenafil?

Confirm the indication is erectile dysfunction and the patient is an adult male.
Check current medicines for nitrates, potent CYP3A4 inhibitors, antihypertensives or alpha‑blockers.
Review cardiac history including recent MI, stroke or unstable angina.
Ascertain hepatic and renal function or history suggesting impairment.
Advise on timing (30–60 minutes prior), need for sexual stimulation and common side effects.
Read the written safety advice, and contact emergency services for priapism or sudden sensory loss.

Getting the best results

How can patients get the best results when using sildenafil?

A trial of the recommended starting dose is advised, with dose adjustment under clinical supervision if efficacy or tolerability requires change.

Follow up with the GP if there is no response after adequate dose titration or if side effects are persistent.

Regulatory status

Sildenafil is a prescription‑only medicine in the UK, and MHRA regulation applies for licensed products. Zenegra is not licensed in the UK.

Suspected adverse reactions can be reported through the Yellow Card scheme.

FAQs and quick‑reference facts

Quick questions and answers

Can women take Zenegra? Not indicated for women.
How soon does it work? Commonly 30–60 minutes.
Maximum dose? 100 mg in 24 hours.
Storage? Store below 25°C in the original blister.
When to seek emergency help? Prolonged erection >4 hours, sudden vision or hearing loss, or collapse from suspected hypotension.

Strengths and pack sizes

Strengths	Typical pack sizes	Manufacturers
25 mg / 50 mg / 100 mg	Blisters of 1, 2, 4, or 10 tablets	Zenegra commonly manufactured by Alkem Laboratories Ltd.; many other global generic manufacturers produce sildenafil.

Check the pack details, and consult your pharmacist about interactions.

Delivery across the United Kingdom

City	Region	Delivery Time
London	England	9–21 days
Birmingham	England	9–21 days
Manchester	England	9–21 days
Glasgow	Scotland	9–21 days
Liverpool	England	9–21 days
Leeds	England	9–21 days
Sheffield	England	9–21 days
Bristol	England	9–21 days
Newcastle Upon Tyne	England	9–21 days
Nottingham	England	9–21 days
Southampton	England	9–21 days
Cardiff	Wales	9–21 days
Belfast	Northern Ireland	9–21 days

Final practical notes

Quick safety reminders

Never take sildenafil with nitrates or if you have a recent history of serious cardiovascular events without specialist advice.

Start at a lower dose if you are elderly or have liver or kidney impairment, and review blood pressure if you are on antihypertensives.

Report severe or unexpected side effects promptly.

Where to get help

If you have concerns about interactions, unexpected symptoms or suspect a counterfeit product, contact your pharmacist or GP straight away.

Report adverse reactions and counterfeit suspicions to the appropriate regulatory bodies such as the Yellow Card scheme and MHRA.